Gokhan S. Hotamisligil

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Biography

The Hotamışlıgil Lab at the Sabri Ülker Center studies innate adaptive pathways involved in metabolic health and diseases such as obesity, diabetes, and cardiovascular disease. For the past 25 years, our lab has made important contributions to the burgeoning field of “immunometabolism” or “metaflammation” studying the interactions between metabolic and immune responses as critical drivers of numerous chronic diseases. In the last decade, we have approached immunometabolism in these two paths: organelle homeostasis and lipid metabolism. Using biochemical, genetic, and physiological studies, we aim to find novel pathways and preventive, therapeutic solutions to today’s greatest threats to global human health.

Education and Training

• PhD, Biological Chemistry and Molecular Pharmacology
  Harvard Medical School
• MD, Medicine
  Ankara University Medical School

Publications

• The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans.

  Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS. Sci Transl Med 2019 04 24

• Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses.

  Prentice KJ, Saksi J, Hotamisligil GS. J Lipid Res 2019 04

• Foundations of Immunometabolism and Implications for Metabolic Health and Disease.

  Hotamisligil GS. Immunity 2017 09 19

• Dual role of fatty acid-binding protein 5 on endothelial cell fate: a potential link between lipid metabolism and angiogenic responses.

  Yu CW, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil GS, Bischoff J, Cataltepe S. Angiogenesis 2016

• Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages.

  Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP. Cell Metab 2015 Dec 01